PP-190 Role of pentoxyfylline (PTX), anti-transforming growth factor β (TGFβ) in modulating hepatic fibrosis in murine schistosomiasis
نویسندگان
چکیده
منابع مشابه
Malnutrition and hepatic fibrosis in murine schistosomiasis.
In this paper, four different approaches attempting to reproduce the schistosomal liver fibrosis in undernourished mice are reported: shifting from a deficient to a balanced diet and vice-versa, repeated infections, influence of the genetic background, and immunological response. Infections were performed with 30 cercariae of Schistosoma mansoni and lasted at least four months. Undernourished m...
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Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...
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Background and aim: The role of transforming growth factor β-1 (TGFβ-1) in neuroendocrine tumour biology is currently unknown. We therefore examined the expression and biological significance of TGFβ signalling components in neuroendocrine tumours (NETs) of the gastroenteropancreatic (GEP) tract. Methods: Expression of TGFβ-1 and its receptors, Smads and Smad regulated proteins, was examined in...
متن کاملHepatic Fibrosis in Schistosomiasis
Schistosomiasis, a disease affecting over 200,000,000 human beings, Is caused by Infection with one of sev eral species of the Schistosoma trematodes. The In fectious form for mammals Is the cercaria developed by passage through snails. The major cause of death In those Infected results from distortion_ of the hepatic circulation caused by a unique kind of fibrosis In the liver. The fibrosis ...
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Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3. At present, TGF-β is considered to be one of the key factors in the pathophy...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2011
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(11)60340-8